WOMEN'S WELLNESS
Progesterone Therapy
Prescription progesterone support for eligible women needing endometrial protection or a clinician-directed perimenopause treatment plan.
What it is
Progesterone therapy commonly uses micronized progesterone prescribed cyclically or continuously. It is often paired with systemic estrogen for women who have a uterus and may also be considered for selected cycle-related concerns.
How it works
Progesterone counterbalances estrogen’s effect on the endometrium and helps reduce the risk of endometrial overgrowth during systemic estrogen therapy. The schedule is chosen according to menstrual status, symptoms, and treatment goals. A clinician evaluates abnormal bleeding and relevant health history before prescribing.
Who it is for
- Women with a uterus using systemic estrogen therapy
- Perimenopausal women needing an individualized cyclic regimen
- Patients who can complete follow-up for bleeding or symptom review
Mechanism in depth
Micronized progesterone is molecularly identical to natural progesterone. Taken orally, it is used in menopausal women with an intact uterus to protect endometrial tissue from estrogen-driven changes. It also has documented effects on sleep and mood through neurosteroid metabolites acting at GABA receptors.
What outcomes to expect
Reported benefits include improved sleep quality within the first week or two of use in many women. Cyclical or continuous dosing is individualized based on symptoms and endometrial protection needs. Bleeding patterns may take several months to stabilize.
Individual response varies. GPLX does not guarantee results. Your physician sets expectations based on your health history and lab findings.
Common side effects
Common effects include drowsiness (which is why oral progesterone is typically taken at bedtime), mild dizziness, breast tenderness, mood changes, and occasional bloating. Rare serious effects include hepatic changes.
Monitoring schedule
Baseline symptom review and, when relevant, pelvic screening. Follow-up at three months and then every six to twelve months. Endometrial safety is a specific focus in women with a uterus on estrogen therapy.
Not appropriate if
Not appropriate if you have hormone-sensitive cancer history, active liver disease, active thrombotic disease, or undiagnosed vaginal bleeding without workup.
Biomarkers reviewed with this treatment
Your physician reviews these markers before and during therapy. Click any marker for a plain-English explanation of what it measures and why it matters.
This treatment is only available after a physician consultation. Membership $39.99/month; consultation $30. Labs and medications billed separately.
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